Post pneumonectomy pulmonary oedema

[Mike Smertka]

Dr. Mattox,
   
  Is there anyhting on the market to inhibit the cytokne release. In my hasty google search all I found were experimental.
   
  Mike

KMATTOX at aol.com wrote:
  Karim: I have seen this in far too many fit young people. It is far 
more common than anyone writes about. Humans with acute cytokine release 
simply do not tolerate acute pneumonectomy and CRASH between 12 and 18 hours. 
Perhaps should be maimntained on membrane oxygenation and other supporting 
mechanisms for 3-5 days. I would suggest you consider a "lung twist" to 
damage control the bleeding. Take back to OR at 8-12 hours and reassess, 
and then back 8-12 hours to reassess. We need to talk about a good protocol 
and a good experimental model. 

k


In a message dated 2/11/2008 9:33:47 P.M. Central Standard Time, 
karim at trauma.org writes:

Initially did well, extubated at 24 hours, comfortable, haemoserous drainage
from chest tubes. 12 hours later after a couple of transient dips in
saturation developed acute pulmonary oedema, froth coming up the ET tube,
and died within minutes. 

Any ideas?





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