RESISTANT Clostridium difficile

[William Bromberg]

What's it sensitive too? What's the recommended regimen?

Bill

>>> <KMATTOX at aol.com> 1/3/2008 11:17 PM >>>
In Houston, particular in the suburbs, cases of SEVERE RESISTANT C.  
Difficile are being seen.    Resistant to both Flagyl and  Vancomycin.    WBCs as high 
as 80,000.   Often in  immunosuppressed patients, but not necessarily in HIV 
infected  patients.   Seems that the patients are on PPI  drugs.     I am 
aware of the CDC reports and a few of the  recent case reports.    From ONE 
hospital in Houston (not mine) I  am aware of 6 cases.      A couple have had 
operations  because even after 8 weeks they were still very sick and at operation 
they had  thickened large bowel.     
 
I am reporting this for two reasons:
 
1.    Have you seen such severe resistance in  C.difficile?
2.    If this is a NEW phenomena, then we need to  spread the word.
 
k



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